Questo recente lavoro su esercizio e obesità e asma, si potrebbe sintetizzare così:
"Uno studio randomizzato condotto su due gruppi di controllo di pazienti obesi in programma di restrizione calorica per il controllo dell'asma, cui è stato associato un differente programma di esercizio fisico, dopo 3 mesi ha dimostrato un migliore controllo di asma, perdita di peso, biomarkers antiinfiammatori e più alti livelli di vitamina D nel gruppo cui sono stati prescritti training aerobico + esercizi di resistenza muscolare rispetto al gruppo che ha eseguito solo esercizi respiratori e di stretching."
Am J Respir Crit Care Med. 2016 Jul 19.
The Role of Exercise in a Weight-loss Program on Clinical Control in Obese Adults with Asthma: a RCT.
Freitas PD1, Ferreira PG2, Silva AG3, Stelmach R4, Carvalho-Pinto RM PhD5, Fernandes FL6, Mancini MC Prof7, Sato MN8, Martins MA9, Carvalho CR10.
Clinical control is difficult to achieve in obese patients with asthma. Bariatric surgery has been recommended for weight-loss and to improve asthma control; however, the benefits of nonsurgical interventions have been poorly investigated.
To examine the effect of exercise training in a weight-loss program on asthma control, quality of life, inflammatory biomarkers and lung function.
Fifty-five obese patients with asthma were randomly assigned to either a weight-loss program + exercise (WL+E group, n=28) or a weight-loss program + sham (WL+S group, n=27) group, where the weight-loss program included nutrition (caloric restriction) and psychological therapies. The WL+E group incorporated aerobic and resistance muscle training, whereas the WL+S group incorporated breathing and stretching exercises.
The primary outcome was clinical improvement in asthma control over 3 months. Secondary outcomes included quality of life, lung function, body composition, aerobic capacity, muscle strength and inflammatory/anti-inflammatory biomarkers.
After 3 months, 51 patients were analyzed. Compared with the WL+S group, the WL+E group demonstrated improved clinical control scores (-0.7 [-1.3, -0.3] vs. -0.3 [-0.9, 0.4]; P=0.01) and greater weight-loss (-6.8%±3.5 vs. -3.1%±2.6; P<0.001) and aerobic capacities (3.0 [2.4, 4.0] vs. 0.9 [-0.3, 1.3] mL O2.kg.min-1; P<0.001). These improvements in the WL+E group were also accompanied by improvements in lung function, anti-inflammatory biomarkers and vitamin D levels, as well as reductions in airway and systemic inflammation.
Adding exercise to a short-term weight-loss program should be considered as a useful strategy to achieving clinical control of asthma in obese patients. Clinical trial registration available at www.clinicaltrials.gov, ID NCT02188940.
asthma; clinical trial; exercise training; inflammation; obesity